Journal article
Effect of spontaneous term labour on the expression of the NR4A receptors nuclear receptor related 1 protein (Nurr1), neuron-derived clone 77 (Nur77) and neuron-derived orphan receptor 1 (NOR1) in human fetal membranes and myometrium
M Lappas
Reproduction Fertility and Development | CSIRO PUBLISHING | Published : 2016
DOI: 10.1071/RD14315
Abstract
Inflammation has been implicated in the mechanisms responsible for human labour. Emerging evidence indicates that nuclear receptor subfamily 4A (NR4A) receptors regulate the transcription of genes involved in inflammation. The aim of the present study was to determine the effect of spontaneous term labour, Toll-like receptor (TLR) ligands and nucleotide-binding oligomerisation domain-containing (NOD) ligands on the expression of nuclear receptor related 1 protein (Nurr1), neuron-derived clone 77 (Nur77) and neuron-derived orphan receptor 1 (NOR1) in human fetal membranes and myometrium. Human fetal membranes and myometrium were collected from term non-labouring women and women after spontane..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
Dr Ratana Lim (Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne) is thanked for her assistance with IHC. The clinical research midwives Genevieve Christophers, Gabrielle Pell and Rachel Murdoch are gratefully acknowledged for assistance with sample collection. The Obstetrics and Midwifery staff of the Mercy Hospital for Women are also thanked for their cooperation. This author is supported by a Career Development Fellowship from the National Health and Medical Research Council (grant no. 1047025). Additional funding for the study was provided by the Medical Research Foundation for Women and Babies and the Mercy Research Foundation.